Novel Si Sabariyah Katrina Full Size Image

Patients that eventually died had at least one risk factor (age65, immunocompromised due to diabetes, corticotherapy, HIV or heart transplantation).

Mechanical ventilation (MV) is a hallmark critical care intervention that is strongly associated with cognitive decline.

Hippocampal blood-brain barrier permeability was quantified using a novel methodology that enabled assessment of small and large molecule permeability across the blood-brain barrier.

Immunohistochemistry was used to assess the regional relationship between amyloid-140 and acute vascular disruption and neuronal injury.

BBB permeability and neuronal injury were decreased in mechanically ventilated ADtg mice, whereas BBB permeability and neuronal injury were increased in mechanically ventilated WT mice compared to their respective SB controls.

There was increased distribution of A1-40 in regions of acute vascular disruption, resulting in lower BBB permeability.

Graph showing significant increase in A1-40 bands area of FITC in ADtg mice subjected to MV compared to SB ADtg mice.

Increased cleaved caspase-3 in the entorhinal cortices of WT mice subjected to MV compared to SB controls.

Novel Si Sabariyah Katrina Full Size Image

Significantly decreased activation of cleaved caspase-3 in the entorhinal cortices of ADtg mice subjected to MV compared to SB ADtg controls Full size image.

Statistica 6.0, parametric methods were used for data analysis.

P004 Procalcitonin and C-reactive protein are not increased in ventriculostomy-related infections in patients with hemorrhagic stroke S Wang, E Pietrzko, E Keller, G Brandi University Hospital Zurich, Neurocritical Care Unit, Dept.

In such patients, diagnosis of VRIs is complicated by blood contamination of CSF following ventricular hemorrhage.

We aimed to evaluate the diagnostic potential of white blood cells count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) to identify VRIs in patients with hemorrhagic stroke during the time of external ventricular drain (EDV) in situ.

A total of 347 patients with hemorrhagic stroke and an external ventricular drain (EVD) were admitted over a 6 years period at the ICU.

Of those, 14 patients with VRIs (VRI), defined by positive CSF bacterial culture and increased WBC in CSF (250ul), and 115 patients without VRIs and with serial CSF sampling (no-VRI) were analyzed.

Patients with CSF-contamination or suspected VRI (negative CSF cultures but antibiotic treatments) were excluded.

For the analysis, mean peak values of WBC, CRP, PCT during the time of EVD in situ were compared between groups (t test).

In the group VRI, PCT was low and significantly lower than in the group no-VRI (0.16 ugl and 2.61ugl, p0.03 in the group VRI and no-VRI, respectively) (panel C).

WBC in CSF were similar between groups (710.14ul and 675.16ul p0.93 in the group VRI and no-VRI, respectively).

Patients admitted to the intensive care unit (ICU) usually present with a severe disease and organ failure, leading to high mortality and morbidity.

Clinical, demographic and outcome data were collected to evaluate its clinical impact on the outcome of patients with CNS infections.

Upon clinical presentation, their most frequent signs were fever (70), meningeal signs (40), seizures (30), and a Glasgow Coma Scale score Streptococcus pneumoniae (n7), Listeria (n5) and Pseudomonas aeruginosa (n4) (Figure 1).

Other gram negative microorganisms were detected and lead to more adverse outcomes.

Meningitis was the cause of admission on 26 patients and on a minority (n4) meningitis was considered to be a secondary diagnosis on patients admitted for other causes (traumatic brain injury, subarachnoid or intraparenchymal hemorrhage, postoperatively of neurosurgical tumor).

Download Novel Si Sabariyah Katrina